The Kikkoman corporation in Japan, undertook a study to research the Antioxidative and Anti-glycation activity of Kokum (Garcinia Indica) fruit rind.
Pintos Kokum Pani is made with Pure and Natural Kokum (Garcinia Indica)
Garcinol is a polyisoprenylated benzophenone derivative. This was extracted from the Kokum fruit rind, and its antioxidative activity, chelating activity, free radical scavenging activity and anti-glycation activity were studied.
Garcinol exhibited moderate antioxidative activity in the micellar linoleic acid preoxidation system and also exhibited chelating activity at almost the same level as citrate.
The study showed nearly 3 times greater DPPH (1, 1-diphenyl -2- picrylhydrazyl) free radical scavenging activity than DL-alpha-tocopherol by weight in aqueous ethanol solution.
In a phenazine methosulfate/NADH-nitroblue tetrazolium system, Kokum fruit rind exhibited superoxide anion scavenging activity and suppressed protein glycation in a bovine serum albumin/fructose system. Thus the study conclued, garcinol might be beneficial as a potent antioxidant and a glycation inhibitor under specified conditions.
Garcinol was purified from Garcinia Indica fruit rind, and its free radical scavenging activity was studied using an electron spin resonance (ESR) spectrometry. In the hypoxanthine/xanthine oxidase system, emulsified garcinol suppressed superoxide anion to almost the same extent as DL-alpha-tocopherol by weight. In the Fenton reaction system, Garcinol also suppressed hydroxyl radical more strongly than DL-Alpha-tocopherol. In the H(2)o(2)/NaOH/DMSO system, Garcinol suppredded superoxide anion, hydroxyl radical and methyl radical. It was thus confirmed that this derivative is a potent free radical scavenger and able to scavenge both hydrophillic and hydrophobic ones, including reactive oxygen species.
Orally adminstered Garcinol prevented acute ulceration in rats induced by indomethacin and water immersion stress caused by radical formation. These results suggested Garcinol might have potential as a free radical scavenger and clinical application as a anti-ulcer drug.
